Keywords: Alzheimer’s disease, capillaries, cerebral amyloid angiopathy, neuropathology More CMBs also increase the probability of underlying CAA. The capillary component correlated with APOE ɛ4, highlighting lobar CMBs as one aspect of CAA phenotypic diversity. Conclusion:Capillary and leptomeningeal/cortical scores correlated with lobar CMBs on MRI but lobar CMBs were more closely associated with the capillary component. Both capillary and the leptomeningeal/cortical components correlated with number of lobar CMBs. Select this result to view Tony Glenn Jagers phone number, address, and more. Tony is related to Jean Ann Peters and Mary Relling Jager as well as 3 additional people. They have also lived in Cross, SC and Mount Pleasant, SC. The capillary CAA component outperformed the leptomeningeal and cortical CAA component in predicting lobar CMBs. The best result we found for your search is Tony Glenn Jager age 50s in Charleston, SC. Both the leptomeningeal and cortical component and the capillary component correlated with lobar-only CMBs. The first rotated component (RPC1) consisted of leptomeningeal and cortical CAA and the second rotated component of capillary CAA (RPC2). The first two components of the PCA analysis of the CAA variables explained 74% variability. Results:MRI-based CMBs appeared in 20/54 (37%). Hurdle models assessed relationships between principal components and lobar CMBs. By a clustering approach, we examined the relationship among CAA variables and performed principal component analysis (PCA) for dimension reduction to produce two scores from these 15 interrelated predictors. Autopsy CAA burden was quantified in each region including leptomeningeal/cortical and capillary CAA. CMBs were quantified on MRIs closest to death. Me thods:We reviewed 54 consecutive participants with antemortem T2*GRE-MRI sequences and subsequent autopsy. Objective:To determine whether CMBs on antemortem MRI correlate with CAA. Ībstract: Background:The relationship between cerebral microbleeds (CMBs) on hemosiderin-sensitive MRI sequences and cerebral amyloid angiopathy (CAA) remains unclear in population-based participants or in individuals with dementia. Ross cĪffiliations: Department of Neurology, Mayo Clinic, Rochester, MN, USA | Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA | Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA | Department of Radiology, Mayo Clinic, Rochester, MN, USA | Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA | Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL, USAĬorrespondence to: Jonathan Graff-Radford, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. b | Vemuri, Prashanthi d | Botha, Hugo a | Jones, David T. a b | Constantopoulos, Eleni c | Rabinstein, Alejandro A.
Authors: Graff-Radford, Jonathan a * | Lesnick, Timothy G.
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